{ "name": "Prostaglandin-Free Lash Serums Compared: 8-Brand Ingredient Breakdown (2026)", "publisher": "SOWN Beauty", "url": "https://sownbeauty.com/pages/prostaglandin-free-lash-serum-comparison", "checked_date": "2026-10-14", "disclosure": "SOWN publishes this comparison. Root 1 is one of the products reviewed. Our methodology and the evidence for every product, including our own, are documented below. SOWN is not affiliated with the other brands listed; their names are trademarks of their owners.", "price_note": "Prices are one-time US purchase prices on each brand's own website, excluding tax, shipping, subscriptions and promotions. Checked October 14, 2026.", "method_note": "Prostaglandin status means no prostaglandin analog appears in the ingredient list the brand discloses (scan terms: prost, cloprost, bimatoprost, latanoprost, travoprost, tafluprost, dechloro, dihydroxy, methylamido, trifluoromethyl, DDDE, MDN). Formulas and labels can change; check the current label.", "sort_order": "Alphabetical by product name; not a ranking.", "status_values": { "verified": "Read on the brand's or regulator's own page and independently re-checked on the checked date", "brand statement": "The brand's own claim; no independent certification or record checked", "not stated": "Not published on the brand's own pages", "unverified": "From a secondary source, or could not be confirmed" }, "prostaglandin_free": [ { "id": "babe-original-renewing", "name": "Babe Original Renewing Lash Serum", "brand": "Babe Original", "official_title": "Renewing Lash Serum", "product_url": "https://babeoriginal.com/products/renewing-serum", "key_actives": { "peptides": [ "Myristoyl Pentapeptide-17", "Myristoyl Pentapeptide-8", "Myristoyl Hexapeptide-16", "Myristoyl Tetrapeptide-12", "Biotinoyl Tripeptide-1", "Copper Tripeptide-1", "Chlorella Vulgaris Sh-Oligopeptide-1", "Sh-Oligopeptide-2", "Sh-Oligopeptide-10", "Sh-Polypeptide-1", "Sh-Polypeptide-11", "Rh-Polypeptide-9", "Nicotiana Benthamiana peptides (3)" ], "botanicals": [ "Swertia Japonica Extract", "Panax Ginseng Root Extract", "Calendula Officinalis Flower Extract", "Ginkgo Biloba Leaf Extract", "Camellia Sinensis Leaf Extract", "Chamomilla Recutita (Matricaria) Flower Extract", "Curcuma Longa (Turmeric) Root Extract", "Vitis Vinifera Seed Extract", "Serenoa Serrulata Fruit Extract", "Hibiscus Sabdariffa Flower Extract", "Arctostaphylos Uva Ursi (Bearberry) Leaf Extract", "Myrothamnus Flabellifolia Leaf/Stem Extract", "Algae: Laminaria Digitata, Pelvetia Canaliculata, Isochrysis Galbana extracts" ], "vitamins": [ "Biotin", "Panthenol", "Ascorbic Acid", "Magnesium Ascorbyl Phosphate", "Tocopherol", "Tocopheryl Acetate" ], "other": [ "Hyaluronic Acid / Sodium Hyaluronate", "Hydrolyzed Keratin", "Silk Amino Acids", "Amino acids (arginine, glycine and others)" ] }, "key_actives_summary": "Peptides (brand: Pro-6 Peptide Complex) + botanicals and algae + vitamins (biotin, panthenol, C, E)", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Water/Aqua/Eau, Glycerin, Butylene Glycol, Swertia Japonica Extract, Sodium Citrate, Leuconostoc/Radish Root Ferment Filtrate, Chlorella Vulgaris Sh-Oligopeptide-1, Arginine, Ascorbic Acid, Polysorbate 20, Gluconolactone, Caprylyl Glycol, Hydroxyethylcellulose, Curcuma Longa (Turmeric) Root Extract, Hyaluronic Acid, Propylene Glycol, Calendula Officinalis Flower Extract, Ethylhexylglycerin, Sodium Benzoate, Ginkgo Biloba Leaf Extract, Sorbitol, Panthenol, Panax Ginseng Root Extract, Vitis Vinifera Seed Extract, Lecithin, Sodium PCA, Phenoxyethanol, Sodium Lactate, Camellia Sinensis Leaf Extract, Chamomilla Recutita (Matricaria) Flower Extract, Tocopheryl Acetate, Yeast Extract, Aminomethyl Propanol, Tocopherol, Pentylene Glycol, PPG-26-Buteth-26, Hydrolyzed Glycosaminoglycans, Aspartic Acid, Myristoyl Pentapeptide-8, PCA, PEG-40 Hydrogenated Castor Oil, Glycine, Copper Tripeptide-1, Serenoa Serrulata Fruit Extract, Silk Amino Acids, Larix Europaea Wood Extract, Urea, Xanthan Gum, Myrothamnus Flabellifolia Leaf/Stem Extract, Magnesium Ascorbyl Phosphate, Sodium Metabisulfite, Alanine, Biotin, Alcohol, Phytic Acid, Serine, Valine, Hydrolyzed Keratin, Helianthus Annuus (Sunflower) Seed Oil, Sodium Hyaluronate, Disodium EDTA, Biotinoyl Tripeptide-1, Myristoyl Hexapeptide-16, Myristoyl Pentapeptide-17, Myristoyl Tetrapeptide-12, Propanediol, Isoleucine, Proline, Threonine, Laminaria Digitata Extract, Pelvetia Canaliculata Extract, Zinc Chloride, Glyceryl Caprylate, Panicum Miliaceum (Millet) Seed Extract, Histidine, Phenylalanine, Apigenin, Phenylpropanol, Polyglyceryl-3 Diisostearate, Carthamus Tinctorius (Safflower) Flower Extract, Hibiscus Sabdariffa Flower Extract, Arctostaphylos Uva Ursi (Bearberry) Leaf Extract, Citric Acid, Eucalyptus Globulus Leaf Extract, Oleanolic Acid, Sh-Oligopeptide-10, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Rh-Polypeptide-9, Isochrysis Galbana Extract, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9, Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2", "vegan": "Yes (brand statement); INCI lists Silk Amino Acids and Hydrolyzed Keratin, often animal-derived", "cruelty_free": "Yes, Leaping Bunny certified (brand statement; directory listing not verified)", "application_frequency": "Twice daily (AM and PM); once satisfied, 2 to 3 times a week to maintain", "use_area": "Lashes (upper lash line only)", "price_usd": 49.0, "size_ml": 6, "price_display": "$49.00", "size_display": "6 mL (4 Month Supply)", "other_sizes": "3 mL (2 Month Supply) $29.00 ($9.67/mL)", "guarantee": "90-day satisfaction guarantee: refund or replacement for babeoriginal.com purchases (separate refund-policy page says 30 days, unused items)", "evidence_summary": "Not publicly available (no study type, participants or duration on the brand's page)", "certifications": "Leaping Bunny (brand statement; not verified in directory)", "notes": [ "Published ingredient list shares nearly all of its ingredients with GrandeLASH Peptide+, in a different order.", "Brand's guarantee page (90 days) and refund-policy page (30 days, unused) conflict; the product page links the guarantee page.", "Brand FAQ says it works with lash extensions.", "Chlorella appears only as Chlorella Vulgaris Sh-Oligopeptide-1 (a biotech peptide), so it is listed under peptides, not algae." ], "sources": [ { "label": "Babe Original Renewing Lash Serum product page", "url": "https://babeoriginal.com/products/renewing-serum" }, { "label": "Babe Original satisfaction guarantee", "url": "https://babeoriginal.com/pages/satisfaction-guarantee" }, { "label": "Babe Original refund policy", "url": "https://babeoriginal.com/policies/refund-policy" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "verified", "guarantee": "brand statement", "evidence_summary": "not stated", "certifications": "unverified", "price_per_ml": "verified" }, "price_per_ml": 8.17, "checked_date": "2026-10-14" }, { "id": "grandelash-peptide-plus", "name": "GrandeLASH Peptide+ (formerly GrandeLASH-Sensitive)", "brand": "Grande Cosmetics", "official_title": "GrandeLASH Peptide+", "product_url": "https://grandecosmetics.com/products/grandelash-peptide", "key_actives": { "peptides": [ "Biotinoyl Tripeptide-1", "Myristoyl Pentapeptide-17", "Copper Tripeptide-1", "Myristoyl Pentapeptide-8", "Myristoyl Hexapeptide-16", "Myristoyl Tetrapeptide-12", "Sh-Oligopeptide-1", "Sh-Oligopeptide-2", "Sh-Oligopeptide-10", "Sh-Polypeptide-1", "Sh-Polypeptide-11", "Rh-Polypeptide-9", "Nicotiana Benthamiana peptides (3)" ], "botanicals": [ "Swertia Japonica Extract", "Panax Ginseng Root Extract", "Calendula Officinalis Flower Extract", "Ginkgo Biloba Leaf Extract", "Camellia Sinensis Leaf Extract", "Chamomilla Recutita (Matricaria) Flower Extract", "Curcuma Longa (Turmeric) Root Extract", "Vitis Vinifera Seed Extract", "Serenoa Serrulata Fruit Extract", "Hibiscus Sabdariffa Flower Extract", "Myrothamnus Flabellifolia Leaf/Stem Extract", "Algae: Laminaria Digitata, Pelvetia Canaliculata, Isochrysis Galbana, Chlorella Vulgaris extracts" ], "vitamins": [ "Biotin", "Panthenol", "Ascorbic Acid", "Magnesium Ascorbyl Phosphate", "Tocopherol", "Tocopheryl Acetate" ], "other": [ "Hyaluronic Acid / Sodium Hyaluronate", "Hydrolyzed Keratin", "Silk Amino Acids", "Amino acids (arginine, glycine and others)" ] }, "key_actives_summary": "Peptides (brand: LashCatalyst blend) + botanicals and algae + vitamins (biotin, panthenol, C, E)", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Aqua/Water/Eau, Glycerin, Butylene Glycol, Swertia Japonica Extract, Arginine, Biotinoyl Tripeptide-1, Ascorbic Acid, Sodium Citrate, Rh-Polypeptide-9, Sh- Oligopeptide-10, Sodium Hyaluronate, Sh-Oligopeptide-2, Myrothamnus Flabellifolia Leaf/Stem Extract, Sh-Polypeptide-1, Sh-Polypeptide-11, Myristoyl Pentapeptide-8, Biotin, Tocopherol, Myristoyl Pentapeptide-17, Lecithin, Glycine, Zinc Chloride, Polydextrose, Threonine, Caprylyl Glycol, Hexylene Glycol, Hyaluronic Acid, Laminaria Digitata Extract, PCA, Calendula Officinalis Flower Extract, Isochrysis Galbana Extract, Helianthus Annuus (Sunflower) Seed Oil, Panicum Miliaceum (Millet) Seed Extract, Ginkgo Biloba Leaf Extract, Valine, Xanthan Gum, Eucalyptus Globulus Leaf Extract, Vitis Vinifera Seed Extract, Camellia Sinensis Leaf Extract, Sh-Oligopeptide-1, Hydroxyethylcellulose, Hydrolyzed Keratin, Phytic Acid, Tocopheryl Acetate, Sorbitol, PEG-40 Hydrogenated Castor Oil, Apigenin, Chlorella Vulgaris Extract, Isoleucine, Disodium EDTA, Curcuma Longa (Turmeric) Root Extract, Yeast Extract, Copper Tripeptide-1, Panthenol, Serine, Propylene Glycol, Nicotiana Benthamiana Octapeptide-30 Sh-Oligopeptide-2, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86, Phenylpropanol, Proline, Glyceryl Caprylate, Magnesium Ascorbyl Phosphate, Gluconolactone, Arctostaphylos Uva Ursi Leaf Extract, Myristoyl Tetrapeptide-12, Polysorbate 20, Urea, Alcohol, Phenoxyethanol, Larix Europaea Wood Extract, Histidine, PPG-26-Buteth-26, Aminomethyl Propanol, Pelvetia Canaliculata Extract, Pentylene Glycol, Calcium Gluconate, Sodium Benzoate, Alanine, Oleanolic Acid, Carthamus Tinctorius (Safflower) Flower Extract, Ethylhexylglycerin, Sodium Lactate, Sodium Metabisulfite, Hibiscus Sabdariffa Flower Extract, Hydrolyzed Glycosaminoglycans, Sodium PCA, Leuconostoc/Radish Root Ferment Filtrate, Panax Ginseng Root Extract, Chamomilla Recutita (Matricaria) Flower Extract, Myristoyl Hexapeptide-16, Phenylalanine, Serenoa Serrulata Fruit Extract, Silk Amino Acids, Aspartic Acid, Polyglyceryl-3 Diisostearate, Citric Acid, Propanediol", "vegan": "Not stated by brand; INCI lists Silk Amino Acids and Hydrolyzed Keratin", "cruelty_free": "Yes, registered with PETA (brand statement; directory listing not verified)", "application_frequency": "Twice daily (AM and PM) until desired results, then every other day to maintain", "use_area": "Lashes (upper lash line only; not lower lash line or brows)", "price_usd": 48.0, "size_ml": 4, "price_display": "$48.00", "size_display": "4 mL (Full Size, 3 Month Supply)", "other_sizes": "2 mL Travel Size (6 Week Supply) $28.00 ($14.00/mL)", "guarantee": "90-day full refund on US domestic orders (from delivery date); return shipping paid by buyer unless Checkout+ was purchased", "evidence_summary": "Consumer study, 33 participants, 16 weeks (per brand; protocol not published)", "certifications": "PETA-registered cruelty-free (brand statement)", "notes": [ "Renamed: Grande published GrandeLASH Peptide+ on 2026-10-02 and states \"Formerly GrandeLASH-Sensitive | New Look, Same Formula\". Legacy listing INCI matches ingredient for ingredient.", "LashCatalyst member peptides (Copper Tripeptide-1, Myristoyl Pentapeptide-17, Biotinoyl Tripeptide-1) are named on the legacy GrandeLASH-Sensitive page FAQ.", "Brand does not recommend use with lash extensions or right after a lash lift because the formula contains oils.", "Legacy GrandeLASH-Sensitive stock status is inconsistent on the brand's site; not stated as fact.", "TikTok Shop orders follow a 30-day window; international returns not accepted." ], "sources": [ { "label": "GrandeLASH Peptide+ product page", "url": "https://grandecosmetics.com/products/grandelash-peptide" }, { "label": "GrandeLASH-Sensitive legacy product page (FAQ)", "url": "https://grandecosmetics.com/products/grandelash-sensitive" }, { "label": "Grande Cosmetics shipping and returns", "url": "https://grandecosmetics.com/pages/shipping-returns" }, { "label": "Grande Cosmetics FAQ", "url": "https://grandecosmetics.com/pages/faq" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "not stated", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "verified", "guarantee": "verified", "evidence_summary": "brand statement", "certifications": "unverified", "price_per_ml": "verified" }, "price_per_ml": 12.0, "checked_date": "2026-10-14" }, { "id": "lashfood-phyto-medic", "name": "LASHFOOD Phyto-Medic Eyelash Enhancer", "brand": "LASHFOOD", "official_title": "Eyelash Enhancing Serum, 3 Month Supply", "product_url": "https://lashfood.com/products/lashfood-phyto-medic-eyelash-enhancer", "key_actives": { "peptides": [], "botanicals": [ "Paeonia Albiflora Root Extract", "Panax Ginseng Root Extract", "Portulaca Oleracea Extract", "Prunus Mume Fruit Extract", "Aloe Barbadensis Leaf Juice", "Bergamot Peel, Lavender Flower and Citrus Orange Fruit waters", "Coconut Fruit Juice" ], "vitamins": [], "other": [ "Hydrolyzed Rice Protein", "Hydrolyzed Soy Protein", "Arginine", "Adenosine", "Trehalose" ] }, "key_actives_summary": "Botanicals + plant proteins; no named peptides or vitamins in the current INCI", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Water, Bergamot Peel Water, Lavender Flower Water, Citrus Orange Fruit Water, Butylene Gylcol , Paeonia Albiflora Root Extract, Panax Ginseng Root Extract, Trehalose, Aloe Barbadensis Leaf Juice, Hydrolyzed Rice Protein, Portulaca Oleracea Extract, Prunus Mume Fruit Extract, Xanthan Gum, Phenethyl Alcohol, Sorbic Acid, Hydrogenated Phosphatidylcholine, Potassium Sorbate, Arginine, Hydrolyzed Soy Protein, Adenosine, Lecithin, Coconut Fruit Juice.", "vegan": "Yes (brand statement)", "cruelty_free": "Yes (brand badge; no certifier named)", "application_frequency": "Once nightly", "use_area": "Lashes", "price_usd": 78.0, "size_ml": 3, "price_display": "$78.00", "size_display": "3 mL (3 Month Supply)", "other_sizes": "2 mL (2 Month Supply) $49.00 ($24.50/mL)", "guarantee": "No results guarantee; 30-day return policy from purchase, shipping deducted, regular-priced items only", "evidence_summary": "16-week study in women aged 19 to 44 (per brand); number of participants not stated", "certifications": "Not verified (brand states an Ecocert certification that we could not confirm in Ecocert's directory)", "notes": [ "The brand's ingredient-story page describes a \"nano-peptide complex\"; no named peptide appears in the current INCI.", "INCI reproduced as published, including the brand's typo \"Butylene Gylcol\".", "Exchanges are for defective or damaged items only." ], "sources": [ { "label": "LASHFOOD Eyelash Enhancing Serum product page", "url": "https://lashfood.com/products/lashfood-phyto-medic-eyelash-enhancer" }, { "label": "LASHFOOD shipping and returns", "url": "https://lashfood.com/pages/shipping-returns" }, { "label": "LASHFOOD before and after (study description)", "url": "https://lashfood.com/pages/before-after" }, { "label": "LASHFOOD ingredient story", "url": "https://lashfood.com/pages/ingredient-story" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "verified", "guarantee": "verified", "evidence_summary": "brand statement", "certifications": "unverified", "price_per_ml": "verified" }, "price_per_ml": 26.0, "checked_date": "2026-10-14" }, { "id": "luna-nectar-moon-boost", "name": "Luna Nectar Moon Boost Lash & Brow Enhancing Serum", "brand": "Luna Nectar", "official_title": "Moon Boost Lash & Brow Enhancing Serum", "product_url": "https://lunanectar.com/products/moon-boost-lash-brow-enhancing-serum", "key_actives": { "peptides": [], "botanicals": [ "Aloe Barbadensis (Aloe Vera) Juice", "Ricinus Communis (Castor) Oil", "Argania Spinosa (Argan) Oil", "Bambusa Vulgaris (Bamboo) Extract", "Laminaria (Algae) Extract", "Prunus Amygdalus Dulcis (Sweet Almond) Oil", "Equisetum Arvense (Horsetail) Extract", "Trifolium Pratense (Red Clover) Extract", "Burdock Root Extract", "Centella Asiatica (Gotu Kola) Extract" ], "vitamins": [ "D-Alpha-Tocopherol (Vitamin E)", "Biotin" ], "other": [ "Lactobacillus Ferment", "Arginine", "Glycerin" ] }, "key_actives_summary": "Plant oils and botanicals + vitamin E and biotin; no peptides", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "*Aloe Barbadensis (Aloe Vera) Juice, *Ricinus Communis (Castor) Oil, *Argania Spinosa (Argan) Oil, *Bambusa Vulgaris (Bamboo) Extract, *Laminaria (Algae) Extract, *Glycerin, *Lactobacillus Ferment, *D-Alpha-Tocopherol (Vitamin E), *Prunus Amygdalus Dulcis (Sweet Almond) Oil, *Sucrose Laurate, *Sorbitan Olivate, *Cetearyl Glucoside, *Equisetum Arvense L. (Horsetail) Extract, *Trifolium Pratense (Red Clover) Extract, *Articum Lappa (Burdock) Root Extract, *Centella Asiatica (Gotu Kola) Extract, *Citrus Aurantium Dulcis (Orange) Fruit Water, *Biotin, *Xanthan Gum, *Arginine *Certified Organic", "vegan": "Yes (brand statement; Provenance \"Vegan Evidenced\")", "cruelty_free": "Yes, Leaping Bunny (per brand; Provenance-verified; not found independently in the Cruelty Free International directory)", "application_frequency": "Once daily, ideally at night", "use_area": "Lashes (upper and lower lash line) and brows", "price_usd": 79.0, "size_ml": 4, "price_display": "$79.00", "size_display": "4 mL (3 month supply)", "other_sizes": null, "guarantee": "30-day money-back guarantee; return in original packaging, original shipping deducted, regular-priced items only", "evidence_summary": "Not publicly available", "certifications": "Leaping Bunny (per brand; Provenance-verified); ingredients marked \"Certified Organic\" at ingredient level, no product-level organic certifier named", "notes": [ "Brand calls it waterless, but the INCI lists Aloe Barbadensis Juice first and also lists Orange Fruit Water.", "INCI reproduced as published, including \"Articum Lappa\" (burdock) and the \"*Certified Organic\" footnote." ], "sources": [ { "label": "Luna Nectar Moon Boost product page", "url": "https://lunanectar.com/products/moon-boost-lash-brow-enhancing-serum" }, { "label": "Luna Nectar refund policy", "url": "https://lunanectar.com/policies/refund-policy" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "verified", "guarantee": "verified", "evidence_summary": "not stated", "certifications": "brand statement", "price_per_ml": "verified" }, "price_per_ml": 19.75, "checked_date": "2026-10-14" }, { "id": "plume-elite", "name": "Plume Elite Prostaglandin-Free Lash & Brow Serum", "brand": "Plume Science", "official_title": "Plume Elite Prostaglandin-Free Lash & Brow Serum", "product_url": "https://www.plumescience.com/products/lash-brow-enhancing-serum-elite", "key_actives": { "peptides": [ "Oligopeptide-251 (OGP-251, proprietary)", "Biotinoyl Tripeptide-1", "Myristoyl Pentapeptide-17", "Myristoyl Hexapeptide-16", "Myristoyl Tetrapeptide-12" ], "botanicals": [ "Ricinus Communis (Castor) Seed Oil", "Carya Ovata (Hickory) Bark Extract", "Coleus Forskohlii" ], "vitamins": [ "Tocopherol", "Panthenol" ], "other": [ "Caffeine" ] }, "key_actives_summary": "Five peptides (brand: Q5 Peptide Complex) + castor oil, hickory bark and coleus forskohlii + vitamin E and panthenol", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Aqua, Ricinus Communis (Castor) Seed Oil, Tocopherol, Propanediol, Carya Ovata (Hickory) Bark Extract, Biotinoyl Tripeptide-1, Myristoyl Pentapeptide-17, Myristoyl Hexapeptide-16, Myristoyl Tetrapeptide-12, Glycerin, Panthenol, Caesalpinia Spinosa (Tara) Gum, Polyglyceryl-6 Laurate, Lauryl Glucoside, Myristyl Glucoside, Caffeine, Coleus Forskohlii, Oligopeptide-251", "vegan": "Yes (brand statement; no certifier named)", "cruelty_free": "Yes (brand statement; no certifier named)", "application_frequency": "Once nightly for 8 weeks, then every other night to maintain", "use_area": "Lashes (upper lash line) and brows", "price_usd": 150.0, "size_ml": 6, "price_display": "$150.00", "size_display": "6 mL (Full Size)", "other_sizes": "3 mL Mini $79.00 ($26.33/mL), same formula per brand", "guarantee": "60-day \"make it right\" policy on the product page; FAQ says cash refunds only for unopened items (refund policy: 30 days, original packaging)", "evidence_summary": "Company-sponsored, single-arm, open-label observational study: 94 enrolled, 85 completed, 8 weeks (not randomized or peer reviewed, per the study record)", "certifications": "None third-party named; brand cites US Patent 11,045,444", "notes": [ "Brand's \"C2 Complex\" is described as Forskolin + Ricinoleic Acid; mapping these to Coleus Forskohlii and castor seed oil in the INCI is our inference.", "A separate retrospective self-report summary covers 30 of the 85 completers who had used Latisse before; not a head-to-head trial.", "Plume Science publishes its own prostaglandin-free comparison page and sells this product.", "Brand states it is compatible with lash extensions, lifts and microblading." ], "sources": [ { "label": "Plume Elite product page", "url": "https://www.plumescience.com/products/lash-brow-enhancing-serum-elite" }, { "label": "Plume Science FAQ", "url": "https://www.plumescience.com/pages/faqs" }, { "label": "Plume Science refund policy", "url": "https://www.plumescience.com/policies/refund-policy" }, { "label": "Plume Science study record (Zenodo)", "url": "https://doi.org/10.5281/zenodo.21633252" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "verified", "guarantee": "brand statement", "evidence_summary": "brand statement", "certifications": "brand statement", "price_per_ml": "verified" }, "price_per_ml": 25.0, "checked_date": "2026-10-14" }, { "id": "sown-root-1", "name": "SOWN Root 1 Lash Serum", "brand": "SOWN Beauty", "official_title": "Root 1 Lash Growth Serum", "product_url": "https://sownbeauty.com/products/root-1-lash-serum", "key_actives": { "peptides": [ "Myristoyl Pentapeptide-17", "Acetyl Tetrapeptide-3", "Biotinoyl Tripeptide-1" ], "botanicals": [ "Panax Ginseng Root Extract (ginseng)", "Lactobacillus/Pumpkin Fruit Ferment Filtrate (pumpkin)", "Morus Alba Root Extract (mulberry root)", "Glycyrrhiza Glabra (Licorice) Root Extract", "Trifolium Pratense (Clover) Flower Extract (red clover)" ], "vitamins": [ "B3 (Niacinamide)", "B5 (Calcium Pantothenate)", "B6 (Pyridoxine HCL)", "B7 (Biotin)", "C (Sodium Ascorbyl Phosphate)", "E (Tocopheryl Acetate)" ], "other": [ "Scutellaria Baicalensis Root Extract", "Camellia Sinensis (Tea) Extract", "Apigenin", "Oleanolic Acid", "Glycine", "Zinc Chloride" ] }, "key_actives_summary": "Three peptides + five botanicals + six vitamins (B3, B5, B6, B7, C, E)", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Aqua (Water), Butylene Glycol, Pentylene Glycol, Glycerin, Ammonium Polyacryloyldimethyl Taurate, Hydroxyacetophenone, Niacinamide, Sodium Starch Octenylsuccinate, Calcium Pantothenate, Maltodextrin, Sodium Ascorbyl Phosphate, Biotin, Morus Alba Root Extract, PPG-26-Buteth-26, PEG- 40 Hydrogenated Castor Oil, Pyridoxine HCL, Tocopheryl Acetate, 1,2-Hexanediol, Caprylyl Glycol, Arctostaphylos Uva Ursi Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Panax Ginseng Root Extract, Scutellaria Baicalensis Root Extract, Lactobacillus/Pumpkin Fruit Ferment Filtrate, Sodium Metabisulfite, Benzoic Acid, Myristoyl Pentapeptide-17, Sodium Benzoate, Dextran, Silica, Gynostemma Pentaphyllum Extract, Apigenin, Glycine, Larix Europaea Wood Extract, Oleanolic Acid, Acetyl Tetrapeptide-3, Trifolium Pratense (Clover) Flower Extract, Biotinoyl Tripeptide-1, Phenoxyethanol*, Leuconostoc/Radish Root Ferment Filtrate, Camellia Sinensis (Tea) Extract, Zinc Chloride.", "vegan": "Yes (brand statement; no third-party certification)", "cruelty_free": "Yes (brand statement; no third-party certification)", "application_frequency": "Twice daily until the first full-size bottle is finished (about 12 weeks), then every other day", "use_area": "Lashes (upper lash line)", "price_usd": 58.0, "size_ml": 3, "price_display": "$58.00", "size_display": "3 mL", "size_footnote": "Size per bottle label.", "other_sizes": "Twin Pack (2 bottles) $95.00 ($15.83/mL)", "guarantee": "Growth Guarantee: \"If you don't get any results in 12 weeks, you get your money back\" (photo steps apply; see terms)", "guarantee_url": "https://sownbeauty.com/pages/growth-guarantee", "evidence_summary": "First-party consumer perception study, 32 participants, 12 weeks", "evidence_qualifier": "Based on 32 participants over a 12-week period. Individual results vary.", "certifications": "None third-party named", "notes": [ "Size is printed on the bottle label but not stated in the product page text.", "Phenoxyethanol appears in the INCI at a trace level (0.0005%, per SOWN's ingredient footnote).", "Root 2 Eyebrow Growth Serum is SOWN's separate brow product.", "Growth Guarantee steps: photos on day 1 and at weeks 4, 8 and 12, emailed to SOWN; the site banner calls it a 90-day guarantee." ], "sources": [ { "label": "SOWN Root 1 product page", "url": "https://sownbeauty.com/products/root-1-lash-serum" }, { "label": "SOWN Growth Guarantee", "url": "https://sownbeauty.com/pages/growth-guarantee" }, { "label": "SOWN refund policy", "url": "https://sownbeauty.com/policies/refund-policy" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "brand statement", "guarantee": "verified", "evidence_summary": "brand statement", "certifications": "not stated", "price_per_ml": "brand statement" }, "price_per_ml": 19.33, "checked_date": "2026-10-14" }, { "id": "the-ordinary-multi-peptide", "name": "The Ordinary Multi-Peptide Lash and Brow Serum", "brand": "The Ordinary", "official_title": "Multi-Peptide Lash and Brow Serum", "product_url": "https://theordinary.com/en-us/multi-peptide-lash-brow-serum-100111.html", "key_actives": { "peptides": [ "Myristoyl Pentapeptide-17", "Biotinoyl Tripeptide-1", "Oligopeptide-2", "Acetyl Tetrapeptide-3" ], "botanicals": [ "Larix Europaea Wood Extract", "Trifolium Pratense Flower Extract", "Camellia Sinensis Leaf Extract" ], "vitamins": [ "Panthenol (provitamin B5)" ], "other": [ "Glycoproteins (Anargy complex)", "Caffeine", "Arginine", "Glycine", "Zinc Chloride" ] }, "key_actives_summary": "Four peptides + three plant extracts + panthenol", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Aqua (Water), Glycerin, Butylene Glycol, Myristoyl Pentapeptide-17, Biotinoyl Tripeptide-1, Oligopeptide-2, Acetyl Tetrapeptide-3, Caffeine, Panthenol, Arginine, Glycine, Glycoproteins, Larix Europaea Wood Extract, Trifolium Pratense Flower Extract, Camellia Sinensis Leaf Extract, Dextran, Maltodextrin, Zinc Chloride, Hydroxyethylcellulose, Xanthan Gum, Trisodium Ethylenediamine Disuccinate, Polysorbate 20, Sodium Metabisulfite, Caprylyl Glycol, 1,2-Hexanediol, Sodium Benzoate, Benzoic Acid, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.", "vegan": "Yes (brand statement; no certifier named)", "cruelty_free": "Yes (brand statement; no certifier named)", "application_frequency": "Twice daily (morning and evening)", "use_area": "Lashes and brows", "price_usd": 14.9, "size_ml": 5, "price_display": "$14.90", "size_display": "5 mL", "other_sizes": null, "guarantee": "No results guarantee; return policy: unwanted products at least 50% full within 365 days, shipping fees non-refundable", "evidence_summary": "Not publicly available", "certifications": "None named", "notes": [ "Brand notes the ingredient list on its page may vary from the box by time and region of purchase.", "US return policy: no store credit or exchanges; Final Sale items non-refundable." ], "sources": [ { "label": "The Ordinary Multi-Peptide Lash and Brow Serum product page", "url": "https://theordinary.com/en-us/multi-peptide-lash-brow-serum-100111.html" }, { "label": "The Ordinary US returns", "url": "https://theordinary.com/en-us/returns.html" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "verified", "guarantee": "verified", "evidence_summary": "not stated", "certifications": "not stated", "price_per_ml": "verified" }, "price_per_ml": 2.98, "checked_date": "2026-10-14" }, { "id": "vegamour-gro-lash", "name": "Vegamour GRO Lash Serum", "brand": "Vegamour", "official_title": "GRO Lash Serum", "product_url": "https://vegamour.com/products/gro-lash-serum", "key_actives": { "peptides": [ "Acetyl Tetrapeptide-3" ], "botanicals": [ "Magnolia Officinalis Bark Extract", "(Trifolium Pratense (Clover)/Vigna Radiata) Sprout Extract", "Trifolium Pratense (Clover) Flower Extract" ], "vitamins": [], "other": [ "Glycerin", "Dextran" ] }, "key_actives_summary": "One peptide + three plant extracts; no vitamins in the INCI", "prostaglandin_scan": "No prostaglandin analog in the disclosed ingredient list", "full_inci": "Water/Aqua/Eau, Pentylene Glycol, Propanediol, Glycerin, Butylene Glycol, Magnolia Officinalis Bark Extract, Gellan Gum, Xanthan Gum, (Trifolium Pratense (Clover)/Vigna Radiata) Sprout Extract, Sodium Benzoate, Potassium Sorbate, Lactic Acid, Dextran, Sodium Hydroxide, Acetyl Tetrapeptide-3, Trifolium Pratense (Clover) Flower Extract", "vegan": "Yes (brand statement; no certifier named)", "cruelty_free": "Yes (brand badge; no certifier named)", "application_frequency": "Twice daily for the first two months, then once daily", "use_area": "Lashes", "price_usd": 68.0, "size_ml": 3, "price_display": "$68.00", "size_display": "3 mL (retailer-listed; not stated on vegamour.com)", "size_footnote": "Vegamour does not state the size on its own site; 3 mL (0.1 fl oz) is the retailer-listed size. Price per mL is based on that figure.", "other_sizes": null, "guarantee": "30-day money-back guarantee; product must be returned, $6.95 handling fee per order, shipping not refunded", "evidence_summary": "Clinical study, 30 participants, 60 days (per brand; sponsor and design not disclosed)", "certifications": "None named", "notes": [ "Brand says to replace the serum every two months.", "Cyber Week purchases are final sale; store credit or exchange available up to 90 days." ], "sources": [ { "label": "Vegamour GRO Lash Serum product page", "url": "https://vegamour.com/products/gro-lash-serum" }, { "label": "Vegamour returns and exchanges", "url": "https://vegamour.com/pages/returns-exchanges" } ], "status": { "full_inci": "verified", "prostaglandin_scan": "verified", "key_actives": "verified", "vegan": "brand statement", "cruelty_free": "brand statement", "application_frequency": "verified", "price_usd": "verified", "size_ml": "unverified", "guarantee": "verified", "evidence_summary": "brand statement", "certifications": "not stated", "price_per_ml": "unverified" }, "price_per_ml": 22.67, "checked_date": "2026-10-14" } ], "prostaglandin_containing_reference": [ { "id": "babe-original-essential", "name": "Babe Original Essential Lash Serum", "brand": "Babe Original", "product_url": "https://babeoriginal.com/products/essential-eyelash-serum", "analog": "Isopropyl Cloprostenate", "analog_label_text": "Isopropyl Cloprostenate (an analog of prostaglandin)", "full_inci": "Water/Aqua/Eau, Glycerin, Sodium Citrate, Panthenol, Leuconostoc/Radish Root Ferment Filtrate, Polysorbate 20, Gluconolactone, Hydroxyethylcellulose, Caprylyl Glycol, Propylene Glycol, Sodium Benzoate, Panax Ginseng Root Extract, Vitis Vinifera Seed Extract, Ethylhexylglycerin, Sodium PCA, Sodium Lactate, Tocopheryl Acetate, Chamomilla Recutita (Matricaria) Flower Extract, Yeast Extract, Arginine, Aspartic Acid, Hydrolyzed Glycosaminoglycans, Alcohol, PCA, Phenoxyethanol, Arctostaphylos Uva Ursi Leaf Extract, Calcium Gluconate, Magnesium Ascorbyl Phosphate, Polydextrose, Glycine, Alanine, Biotin, Serine, Valine, Sodium Hyaluronate, Isopropyl Cloprostenate (an analog of prostaglandin), Isoleucine, Proline, Threonine, Hexylene Glycol, Histidine, Phenylalanine, Aminomethyl Propanol.", "regulatory_status": { "us": "Sold as a cosmetic in the US", "sccs_1680_25": "Isopropyl cloprostenate is one of the three prostaglandin analogs assessed in SCCS/1680/25", "health_canada": "Isopropyl cloprostenate is named on Health Canada's Cosmetic Ingredient Hotlist (prohibited in cosmetics)" }, "price_usd": 49.0, "size_ml": 2, "price_display": "$49.00", "size_display": "2 mL (3 Month Supply)", "other_sizes": "1 mL $29.00; 4 mL $89.00", "application_frequency": "Nightly (beginners every 2 to 3 days); 2 to 3 times a week to maintain", "notes": [ "Brand label: \"This product contains a small amount of isopropyl cloprostenate, a synthetic prostaglandin analog.\"" ], "sources": [ { "label": "Babe Original Essential Lash Serum product page", "url": "https://babeoriginal.com/products/essential-eyelash-serum" } ], "status": { "analog": "verified", "price_usd": "verified", "size_ml": "verified", "regulatory_status": "verified" }, "prostaglandin_scan": "Prostaglandin analog listed: Isopropyl Cloprostenate (an analog of prostaglandin)", "price_per_ml": 24.5, "checked_date": "2026-10-14" }, { "id": "grandelash-md", "name": "GrandeLASH-MD", "brand": "Grande Cosmetics", "product_url": "https://grandecosmetics.com/products/grandelash-md", "analog": "Isopropyl Cloprostenate", "analog_label_text": "Isopropyl Cloprostenate (an analog of prostaglandin)", "full_inci": "Water/Aqua/Eau, Panthenol, Glycerin, Sodium Citrate, Leuconostoc/Radish Root Ferment Filtrate, Alanine, Alcohol, Aloe Barbadensis Leaf Juice, Arctostaphylos Uva URSI Leaf Extract, Arginine, Aspartic Acid, Calcium Gluconate, Caprylyl Glycol, Chamomilla Recutita (Metricaria) Flower Extract, Ethylhexylglycerin, Gluconolactone, Glycine, Hexylene Glycol, Histidine, Honey Extract/Mel/Extrait de Miel, Hydrolyzed Glycosaminoglycans, Hydrolyzed Yeast Extract, Hydroxyethylcellulose, Isoleucine, Isopropyl Cloprostenate (an analog of prostaglandin) , Magnesium Ascorbyl Phosphate, Panax Ginseng Root Extract, PCA, Phenylalanine, Polysorbate 20, Proline, Propylene Glycol, Serine, Sodium Hyaluronate, Sodium Lactate, Sodium PCA, Threonine, Tocopheryl Acetate, Triethanolamine, Tussilago Farfara (Coltsfoot) Leaf Extract, Valine, Vitis Vinifera (Grape) Seed Extract, Phenoxyethanol, Sodium Benzoate, Sodium Metabisulfite", "regulatory_status": { "us": "Sold as a cosmetic in the US", "sccs_1680_25": "Isopropyl cloprostenate is one of the three prostaglandin analogs assessed in SCCS/1680/25", "health_canada": "Isopropyl cloprostenate is named on Health Canada's Cosmetic Ingredient Hotlist (prohibited in cosmetics)" }, "price_usd": 68.0, "size_ml": 2, "price_display": "$68.00", "size_display": "2 mL (3 Month Supply)", "other_sizes": "1 mL $36.00; 4 mL $125.00", "application_frequency": "Daily for 3 months, then every other day to maintain", "notes": [ "Brand label: \"This cosmetic product contains (a small amount of) isopropyl cloprostenate, an analog of prostaglandin.\"" ], "sources": [ { "label": "GrandeLASH-MD product page", "url": "https://grandecosmetics.com/products/grandelash-md" } ], "status": { "analog": "verified", "price_usd": "verified", "size_ml": "verified", "regulatory_status": "verified" }, "prostaglandin_scan": "Prostaglandin analog listed: Isopropyl Cloprostenate (an analog of prostaglandin)", "price_per_ml": 34.0, "checked_date": "2026-10-14" }, { "id": "latisse", "name": "Latisse (bimatoprost ophthalmic solution) 0.03%", "brand": "Allergan (AbbVie)", "product_url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=34f83d9d-2c64-463e-8a90-9a460fedfead", "analog": "Bimatoprost 0.03%", "analog_label_text": "bimatoprost ophthalmic solution 0.03%", "full_inci": null, "regulatory_status": { "us": "FDA-approved prescription drug (\"Rx only\"); not a cosmetic", "sccs_1680_25": "Not one of the three analogs in SCCS/1680/25 (that opinion covers cosmetic lash and brow products)", "health_canada": "Bimatoprost is named on Health Canada's Cosmetic Ingredient Hotlist (prohibited in cosmetics)" }, "price_usd": null, "size_ml": 3, "price_display": "Prescription; price varies by pharmacy", "size_display": "3 mL or 5 mL", "other_sizes": "3 mL (70 applicators) or 5 mL (140 applicators), per the label", "application_frequency": "Once nightly, upper eyelid margin", "notes": [ "Label evidence: multicenter, double-masked, randomized, vehicle-controlled study, 278 adults, four months (prescribing information section 6.1).", "Product URL is the FDA label on DailyMed (current SPL version December 23, 2025)." ], "sources": [ { "label": "Latisse prescribing information (DailyMed)", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=34f83d9d-2c64-463e-8a90-9a460fedfead" } ], "status": { "analog": "verified", "price_usd": "not stated", "size_ml": "verified", "regulatory_status": "verified" }, "prostaglandin_scan": "Prostaglandin analog listed: bimatoprost ophthalmic solution 0.03%", "price_per_ml": null, "checked_date": "2026-10-14" }, { "id": "nutraluxe-lash", "name": "NutraLuxe Lash", "brand": "NutraLuxe MD", "product_url": "https://www.nutraluxemd.com/products/nutraluxe-lash", "analog": "Isopropyl Cloprostenate (per an ingredient image on the brand's product page; current formula not confirmed in page text)", "analog_label_text": "Isopropyl Cloprostenate", "full_inci": "Aqua, Glycerin, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate, Panthenol, Vitis Vinifera (Grape) Seed Extract, Polysorbate 20, Sodium Lactate, Sodium Pca, Sorbitol, Isopropyl Cloprostenate, Proline, Hydroxyethylcellulose, Panax Ginseng Root Extract, Chamomilla Recutita (Matricaria) Flower Extract, Arctostaphylos Uva Ursi Leaf Extract, Magnesium Ascorbyl Phosphate, Tocopheryl Acetate, Triethanolamine, Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isobutylparaben.", "regulatory_status": { "us": "Brand calls it a cosmetic product and \"not a drug product\"", "sccs_1680_25": "If the image ingredient list is current, isopropyl cloprostenate is one of the three analogs assessed in SCCS/1680/25", "health_canada": "If the image ingredient list is current, isopropyl cloprostenate is named on Health Canada's Cosmetic Ingredient Hotlist (prohibited in cosmetics)" }, "price_usd": 49.0, "size_ml": 1.5, "price_display": "$49.00", "size_display": "1.5 mL", "other_sizes": "3.0 mL $79.00; 4.5 mL $99.00", "application_frequency": "Once daily", "notes": [ "No ingredient list in the page text; the ingredient image in the product gallery dates from February 2022.", "Page text also calls the product \"NutraLuxe Eyelash Conditioner\"." ], "sources": [ { "label": "NutraLuxe Lash product page", "url": "https://www.nutraluxemd.com/products/nutraluxe-lash" } ], "status": { "analog": "unverified", "price_usd": "verified", "size_ml": "verified", "regulatory_status": "unverified" }, "prostaglandin_scan": "Prostaglandin analog listed: Isopropyl Cloprostenate", "price_per_ml": 32.67, "checked_date": "2026-10-14" }, { "id": "revitalash-advanced", "name": "RevitaLash Advanced Eyelash Conditioner", "brand": "RevitaLash Cosmetics", "product_url": "https://www.revitalash.com/products/revitalash-advanced-eyelash-conditioner", "analog": "Ethylcloprostenolamide", "analog_label_text": "Ethylcloprostenolamide (a prostaglandin analogue)", "full_inci": "Aqua/Water/Eau, Ammonium Acryloyldimethyltaurate/Carboxyethyl Acrylate Crosspolymer, Glycerin, Biotin, Caprylic/Capric Triglyceride, Polyglyceryl-10 Dioleate, Phenoxyethanol, Phenylpropanol, Propanediol, Caprylyl Glycol, Sodium Citrate, Polyglyceryl-10 Dipalmitate, Sodium Hydroxide, Ethylcloprostenolamide (a prostaglandin analogue), Biotinoyl Tripeptide-1, Linum Usitatissimum (Linseed) Seed Extract, Xanthan Gum, Octapeptide-2, Calendula Officinalis Flower Extract, Panax Ginseng Root Extract, Serenoa Serrulata Fruit Extract, Camellia Sinensis Leaf Extract, Tocopherol, Swertia Japonica Extract.", "regulatory_status": { "us": "Sold as a cosmetic in the US", "sccs_1680_25": "The label name, ethylcloprostenolamide, is not one of the three names in SCCS/1680/25", "health_canada": "Not named individually on Health Canada's Cosmetic Ingredient Hotlist; the prohibited entry covers \"Prostaglandins, their salts and derivatives and their analogs\"" }, "price_usd": 100.0, "size_ml": 2.0, "price_display": "$100.00", "size_display": "2.0 mL (3 months)", "other_sizes": "1.0 mL $59.00; 3.5 mL (6 months) $152.00", "application_frequency": "Once daily, upper lashes only", "notes": [ "Brand caution: \"This cosmetic product contains a small amount of an ingredient classified as a prostaglandin analogue.\"", "Stated by label name only; whether ethylcloprostenolamide is the same compound as DDDE is not verified.", "Brand site blocks automated fetches; facts were read from a browser-rendered page on 2026-10-14." ], "sources": [ { "label": "RevitaLash Advanced product page", "url": "https://www.revitalash.com/products/revitalash-advanced-eyelash-conditioner" }, { "label": "RevitaLash FAQ", "url": "https://www.revitalash.com/pages/faq" } ], "status": { "analog": "verified", "price_usd": "verified", "size_ml": "verified", "regulatory_status": "verified" }, "prostaglandin_scan": "Prostaglandin analog listed: Ethylcloprostenolamide (a prostaglandin analogue)", "price_per_ml": 50.0, "checked_date": "2026-10-14" } ], "regulatory_sources": [ { "label": "European Commission SCCS Final Opinion SCCS/1680/25 on prostaglandin analogues (MDN, IPCP, DDDE)", "url": "https://health.ec.europa.eu/publications/sccs-prostaglandin-analogues-methylamido-dihydro-noralfaprostal-mdn-isopropyl-cloprostenate-ipcp_en", "statement": "Adopted February 2, 2026 (published February 10, 2026). The EU's Scientific Committee on Consumer Safety assessed isopropyl cloprostenate (IPCP), methylamido-dihydro-noralfaprostal (MDN) and dechloro dihydroxy difluoro ethylcloprostenolamide (DDDE) and stated that \"the SCCS is of the opinion that none of them can be considered safe for use in cosmetic products intended for promoting the growth of eyelashes and eyebrows.\"", "status": "verified" }, { "label": "SCCS/1680/25 Final Opinion (PDF)", "url": "https://health.ec.europa.eu/document/download/55295a0e-1aa8-4380-a8db-84ecf85b711c_en?filename=sccs_o_302.pdf", "statement": "Full text of the opinion; the DDDE section is titled \"Dechloro Dihydroxy Difluoro Ethylcloprostenolamide (DDDE) or Ethyl Tafluprostamide\".", "status": "verified" }, { "label": "Health Canada Cosmetic Ingredient Hotlist", "url": "https://www.canada.ca/en/health-canada/services/consumer-product-safety/cosmetics/cosmetic-ingredient-hotlist-prohibited-restricted-ingredients/hotlist.html", "statement": "Health Canada's Cosmetic Ingredient Hotlist lists prostaglandins and their analogs, including isopropyl cloprostenate and bimatoprost by name, as prohibited in cosmetics.", "status": "verified" }, { "label": "Latisse (bimatoprost ophthalmic solution) 0.03% prescribing information, DailyMed", "url": "https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=34f83d9d-2c64-463e-8a90-9a460fedfead", "statement": "FDA-approved prescription label (\"Rx only\"). Section 5.2: \"Patients should be advised about the potential for increased brown iris pigmentation which is likely to be permanent.\"", "status": "verified" }, { "label": "UK Office for Product Safety and Standards: Prostaglandin analogues in cosmetics (December 5, 2024)", "url": "https://www.gov.uk/government/publications/prostaglandin-analogues-in-cosmetics", "statement": "OPSS notes that \"prostaglandin analogues are used as active ingredients in medicinal products requiring a doctor's prescription in the UK.\"", "status": "verified" }, { "label": "Baiyasi M, et al. Eyelash serums: A comprehensive review. J Cosmet Dermatol. 2024;23(7):2328-2344", "url": "https://pubmed.ncbi.nlm.nih.gov/38475901/", "statement": "Review abstract: non-prostaglandin ingredients \"show promising data, more studies are needed due to a lack of formal evidence in eyelash serum use.\"", "status": "verified" } ] }